Tyrosine kinase inhibitors in BCR-ABL positive acute lymphoblastic leukemia
نویسندگان
چکیده
منابع مشابه
Tyrosine kinase inhibitors induce mesenchymal stem cell-mediated resistance in BCR-ABL+ acute lymphoblastic leukemia.
Tyrosine kinase inhibitors (TKIs) are used as a frontline therapy for BCR-ABL(+) acute lymphoblastic leukemia (ALL). However, resistance to TKI therapy arises rapidly, and its underlying molecular mechanisms are poorly understood. In this study, we identified a novel cascade of events initiated by TKIs and traversing through mesenchymal stem cells (MSCs) to leukemic cells, leading to resistance...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2015
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2015.124016